• Neurology · Aug 1994

    High-dose intravenous lorazepam for the treatment of refractory status epilepticus.

    • D R Labar, A Ali, and J Root.
    • Department of Neurology, New York Hospital-Cornell Medical Center, New York 10021.
    • Neurology. 1994 Aug 1; 44 (8): 1400-3.

    AbstractWe treated nine refractory status epilepticus cases with high-dose intravenous lorazepam. We monitored the EEGs continuously, and lorazepam dosing was titrated to stop clinical and electrographic seizures. Lorazepam doses needed to terminate status epilepticus ranged from 0.3 to 9 mg/hr. Lorazepam did not cause hypotension. All patients survived. Outcome was complete recovery in two cases, moderate disability in four, and severe disability in three. These findings suggest high-dose intravenous lorazepam may be an effective alternative to pentobarbital for the treatment of severe status epilepticus.

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