• Rev Med Brux · Nov 2007

    Review

    [Mechanisms of neuronal death in Huntington's disease. Second part: therapeutic challenges].

    • K Bantubungi and D Blum.
    • INSERM U837, Centre de Recherche Jean-Pierre Aubert. Bantubungi@lille.inserm.fr
    • Rev Med Brux. 2007 Nov 1; 28 (6): 487-94.

    AbstractHuntington's disease is caused by an abnormal CAG expansion within the gene encoding Huntingtin which induces a major cortico-striatal degeneration as well as motor and cognitive impairments. Since the discovery of the present mutation, a number of experimental data have been collected to uncover the physiopathological consequences of mutated Huntingtin expression. Here, we review the therapeutic challenges of Huntington's disease.

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