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Randomized Controlled Trial Clinical Trial
Pancuronium prevents pneumothoraces in ventilated premature babies who actively expire against positive pressure inflation.
- A Greenough, S Wood, C J Morley, and J A Davis.
- Lancet. 1984 Jan 7;1(8367):1-3.
AbstractPreterm infants who were making expiratory efforts against ventilator inflation were randomised to be paralysed with pancuronium or to receive no paralysing agent during ventilation. Pneumothoraces developed in all 11 unparalysed babies but in only 1 of 11 (p less than 0.0004) of those managed with pancuronium, which had no serious side-effects. In 34 infants excluded from the trial because they were not breathing against the ventilator, no pneumothoraces developed.
This article appears in the collection: The 20 most cited pediatric anesthesia articles.
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Daniel Jolley