• Serife Gokbulut Bektas, Sema Turan, Umit Karadeniz, Burcin Ozturk, Soner Yavas, Dilan Biricik, Gul Sevim Saydam, and Ozcan Erdemli.
• Department of Anesthesiology and Reanimation, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
• Biomed Res Int. 2015 Jan 1; 2015: 658678.

BackgroundOur study aimed to compare HTEA and intravenous patient-controlled analgesia (PCA) in patients undergoing coronary bypass graft surgery (CABG), based on haemodynamic parameters and myocardial functions.Materials And MethodsThe study included 34 patients that were scheduled for elective CABG, who were randomly divided into 2 groups. Anesthesia was induced and maintained with total intravenous anesthesia in both groups while intravenous PCA with morphine was administered in Group 1 and infusion of levobupivacaine was administered from the beginning of the anesthesia in Group 2 by thoracic epidural catheter. Blood samples were obtained presurgically, at 6 and 24 hours after surgery for troponin I, creatinine kinase-MB (CK-MB), total antioxidant capacity, and malondialdehyde. Postoperative pain was evaluated every 4 hours until 24 hours via VAS.ResultsThere were significant differences in troponin I or CK-MB values between the groups at postsurgery 6 h and 24 h. Heart rate and mean arterial pressure in Group 1 were significantly higher than in Group 2 at all measurements. Cardiac index in Group 2 was significantly higher than in Group 1 at all measurements.ConclusionPatients that underwent CABG and received HTEA had better myocardial function and perioperative haemodynamic parameters than those who did not receive HTEA.

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