• Ann Pharm Fr · May 2014

    Review

    Continuous infusion of piperacillin/tazobactam in patients with severe infections: A possible pharmacokinetic optimisation?

    • D Attivi and S Gibaud.
    • Centre Hospitalier de l'Ouest Vosgien (CHOV), 1280, avenue de la Division-Leclerc, 88300 Neufchâteau, France.
    • Ann Pharm Fr. 2014 May 1; 72 (3): 146-51.

    AbstractPiperacillin/Tazobactam is a time-dependent antimicrobial combination (beta-lactam/beta-lactamase inhibitor) commonly used in the treatment of severe Gram-negative infections. The optimisation of its time-dependent bactericidal activity via continuous infusion could improve clinical outcomes. Several studies have been realized on the relevance of a continuous infusion, but, to date, no definitive position can be adopted on the matter and a well-designed randomized controlled trial is warranted. In other articles, continuous infusion regimens are also more cost efficient. This article is an update, including the most recent trials about this subject.Copyright © 2014 Elsevier Masson SAS. All rights reserved.

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