• Psychiatry research · Aug 2013

    Randomized Controlled Trial Multicenter Study

    Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder.

    • Seth C Hopkins, David S Reasner, and Kenneth S Koblan.
    • Sunovion Pharmaceuticals Inc, 84 Waterford Dr., Marlborough, MA 01752, USA. seth.hopkins@sunovion.com
    • Psychiatry Res. 2013 Aug 15; 208 (3): 285-7.

    AbstractResponses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial. Improvements in depression scores among subjects with Val/Val genotypes were larger than those in Met/Met genotypes, suggesting that venlafaxine may alter noradrenergic flux differentially according to COMT activity.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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