• Vet Hum Toxicol · Dec 2000

    Rapid determination of ethylene glycol and glycolic acid in biological fluids.

    • R A Smith and D G Lang.
    • Livestock Disease Diagnostic Center, Department of Veterinary Science, University of Kentucky, Lexington 40511, USA.
    • Vet Hum Toxicol. 2000 Dec 1; 42 (6): 358-60.

    AbstractEthylene glycol poisoning of companion animals is a common occurrence and is sometimes involved in human intoxication. Ethylene glycol is of limited toxicity, but the metabolites including glycolic acid are responsible for poisoning. Conventional treatment has employed substances to prevent alcohol dehydrogenase from metabolizing the ethylene glycol, but to be effective, therapy must begin within hours of ethylene glycol consumption. We describe a rapid (10 min) analysis of biological fluids for ethylene glycol and glycolic acid using isocratic HPLC, a refractive index detector, and a Waters fast fruit juice analytical column.

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