• Yu-Chan Lee, Hao-Chien Wang, Chia-Lin Hsu, Huey-Dong Wu, Han-Shui Hsu, and Cheng-Deng Kuo.
• Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Division of Respiratory Therapy, Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei, Taiwan, ROC.
• J Chin Med Assoc. 2016 Feb 1; 79 (2): 72-6.

BackgroundWhen to extubate the endotracheal tube is controversial in patients with depressed mental status. The use of the Glasgow Coma Scale (GCS) with score 8 or above as a criterion for extubation by many investigators is questionable.MethodsA total of 133 consecutive patients (M/F: 86/47; age: 71 ± 17 years) admitted to the respiratory care center (RCC) of the hospital were enrolled. The effects of GCS score on the outcomes and weaning rate of the patients were evaluated.ResultsThe mortality rate was significantly higher in patients with a GCS score<7T or derived GCS (dGCS) score < 10 (p = 0.011). In patients with a low GCS score (GCS < 7T or dGCS score < 10), the rate of successful ventilator weaning in patients with tracheostomy was significantly higher than that in patients without tracheostomy (GCS and dGCS: 94.4% vs. 38.5%, p = 0.001). However, tracheostomy in patients with a high GCS (GCS score ≥ 7T or dGCS score ≥ 10) did not lead to a higher success rate of weaning. In multivariable analysis, tracheostomy was still an independent determinant of successful weaning in patients with low GCS.ConclusionTracheostomy increases the success rate of weaning in patients with low GCS, but not in patients with high GCS. Mental status graded by GCS did affect the outcomes in patients with conscious disturbance in the RCC. The low tracheostomy rate in patients with low GCS affected the rate of successful weaning, which might have contributed to the higher mortality rate in patients with low GCS in the RCC.Copyright © 2015. Published by Elsevier Taiwan LLC.

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