• Terry C Yin, Jeremiah K Britt, Héctor De Jesús-Cortés, Yuan Lu, Rachel M Genova, Michael Z Khan, Jaymie R Voorhees, Jianqiang Shao, Aaron C Katzman, Paula J Huntington, Cassie Wassink, Latisha McDaniel, Elizabeth A Newell, Laura M Dutca, Jacinth Naidoo, Huxing Cui, Alexander G Bassuk, Matthew M Harper, Steven L McKnight, Joseph M Ready, and Andrew A Pieper.
• Department of Psychiatry, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
• Cell Rep. 2014 Sep 25; 8 (6): 1731-40.

AbstractThe P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage. Initiation of daily treatment with our recently reported lead agent, P7C3-S243, 1 day after blast-mediated TBI blocks axonal degeneration and preserves normal synaptic activity, learning and memory, and motor coordination in mice. We additionally report persistent neurologic deficits and acquisition of an anxiety-like phenotype in untreated animals 8 months after blast exposure. Optimized variants of P7C3 thus offer hope for identifying neuroprotective agents for conditions involving axonal damage, neuronal cell death, or both, such as occurs in TBI.Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

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