• Sleep · Jan 2015

    Sleep apnea and the risk of chronic kidney disease: a nationwide population-based cohort study.

    • Yi-Che Lee, Shih-Yuan Hung, Hao-Kuang Wang, Chi-Wei Lin, Hsi-Hao Wang, Shih-Wei Chen, Min-Yu Chang, Li-Chun Ho, Yi-Ting Chen, Hung-Hsiang Liou, Tsuen-Chiuan Tsai, Shih-Hann Tseng, Wei-Ming Wang, Sheng-Hsiang Lin, and Yuan-Yow Chiou.
    • Division of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
    • Sleep. 2015 Jan 1; 38 (2): 213-21.

    Study ObjectivesSleep apnea (SA) is characterized by apnea during sleep and is associated with cardiovascular diseases and an increase in all-cause mortality. Chronic kidney disease (CKD) is a global health problem that has placed a substantial burden on healthcare resources. However, the relationship between SA and the incidence of CKD is not clear. This study aimed to determine whether SA is an independent risk factor for the development of CKD.DesignRetrospective cohort study.SettingNational Health Insurance Research Database (NHIRD) of Taiwan.Patients Or ParticipantsA total of 4,674 adult patients (age ≥ 30 y) in whom SA was newly diagnosed from 2000 to 2010 were included, together with 23,370 non-SA patients as the comparison group. The two groups were frequency-matched for sex, age, and year of receiving medical service. Each individual was followed until 2011.InterventionsN/A.Measurements And ResultsThese two groups were monitored and observed for the occurrence of CKD. Patients with SA experienced a 1.94-fold increase (95% confidence interval [CI], 1.52-2.46; P < 0.001) in the incidence of CKD, which was independent of sex, age, and comorbid medical conditions. Additionally, they showed a 2.2-fold increase (95% CI, 1.31-3.69; P < 0.01) in the incidence of end-stage renal disease (ESRD).ConclusionsPatients with sleep apnea are at increased risk for chronic kidney disease and end-stage renal disease compared with the general population. As such, screening renal function and treatment of chronic kidney disease is an important issue in patients with sleep apnea.© 2015 Associated Professional Sleep Societies, LLC.

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