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Scand. J. Infect. Dis. · Nov 2014
High vancomycin minimum inhibitory concentration is associated with poor outcome in patients with methicillin-susceptible Staphylococcus aureus bacteremia regardless of treatment.
- Juan José Castón, Francisco González-Gasca, Lourdes Porras, Soledad Illescas, Maria Dolores Romero, and Julio Gijón.
- From the Unidad de Enfermedades Infecciosas, Hospital General Universitario de Ciudad Real, Universidad de Castilla La Mancha , Ciudad Real , Spain.
- Scand. J. Infect. Dis. 2014 Nov 1; 46 (11): 783-6.
AbstractWe retrospectively investigated the impact of high vancomycin minimum inhibitory concentration (MIC > 2 μg/ml) on the outcome of 53 patients with bacteremia caused by methicillin-susceptible Staphylococcus aureus (MSSA). Vancomycin MIC was determined by broth microdilution according to CLSI methods. The primary outcome was 30-day all-cause mortality from the date of the first positive blood culture. The mortality rate was 22.6% (12 of 53 patients). High vancomycin MIC (odds ratio (OR) = 9.3; 95% confidence interval (95% CI) = 1.31-63.20; p = 0.027), Charlson comorbidity index ≥ 3 (OR = 10.3; 95% CI = 1.3-102.04; p = 0.03), advanced age (OR = 35.8; 95% CI = 2.3-659.2; p = 0.01), and severe sepsis (OR = 8.5; 95% CI = 1.2-61.4; p = 0.03) were associated with mortality.
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