• Journal of neurosurgery · Sep 1985

    Randomized Controlled Trial Clinical Trial

    Use of intrathecal morphine for postoperative pain relief following lumbar spine surgery.

    • P O'Neill, C Knickenberg, S Bogahalanda, and A E Booth.
    • J. Neurosurg. 1985 Sep 1; 63 (3): 413-6.

    AbstractA randomized prospective double-blind trial of intrathecal morphine for postoperative pain relief following lumbar spine surgery is described. Intrathecal morphine significantly reduced the mean pain score in the postoperative period (p less than 0.01) and there was a corresponding significant reduction in the need for additional postoperative analgesia (p less than 0.05). The possible mechanism of action of intrathecal morphine and the potential advantages of this technique are discussed. Possible side effects are also considered, and caution is urged until wider experience has been obtained.

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