• Infection · Feb 2004

    Review Case Reports

    Isolated bacterial meningitis as the key syndrome of infective endocarditis.

    • K Angstwurm, E Halle, K Wetzel, J Schultze, E Schielke, and J R Weber.
    • Dept. of Neurology, Charité, Humboldt-University, D-10098, Berlin, Germany. klemens.angstwurm@charite.de
    • Infection. 2004 Feb 1; 32 (1): 47-50.

    BackgroundBacterial meningitis is an unusual first manifestation but a major complication of infective endocarditis.Patients And MethodsWe present three well documented cases of isolated bacterial meningitis in endocarditis. Against this background we review the literature.ResultsAll patients presented with bacterial meningitis. Staphylococcus aureus was isolated in blood cultures of all patients, but was found only in the cerebrospinal fluid (CSF) of one patient. The underlying endocarditis was confirmed histologically in all three cases. Two patients recovered completely and one died.ConclusionAn extensive search for endocarditis is recommended in every case of an unusual isolate in bacterial meningitis whether it is isolated from blood or CSF.

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