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Review Case Reports
[A disseminated form of Langerhans histiocytosis associated with diabetes insipidus and diabetes mellitus].
- I Ben Ghorbel, M H Houman, S B'chir, S Chamakhi, and M Miled.
- Service de médecine interne, hôpital La Rabta, 1007 Tunis, Tunisie.
- Rev Med Interne. 2001 May 1; 22 (5): 469-74.
IntroductionLangerhans' cell histiocytosis is a rare disorder of unknown etiology characterized by a wide clinical spectrum and varied behavior. Diabetes insipidus is a relatively common feature in Langerhans' cell histiocytosis. The presence of both diabetes insipidus and mellitus associated with histiocytosis in an adult is rare. To our knowledge, only three previous cases have been reported.ExegesisWe report the clinical presentation, pathologic findings and clinical progress in an adult female who had disseminated Langerhans' cell histiocytosis (hypothalamic infiltration, multifocal bone involvement) associated with both diabetes insipidus and mellitus.ConclusionThe pathogenesis of diabetes mellitus in such an association will be discussed.
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