• Adv Exp Med Biol · Jan 1999

    Case Reports

    Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.

    • G Filosa, F Salaffi, and L Bugatti.
    • Division of Dermatology, A. Murri Hospital Jesi (An), Italy. gfilos@tin.it
    • Adv Exp Med Biol. 1999 Jan 1; 455: 521-4.

    AbstractAccelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.

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