• Shoji Yokobori, Janek Frantzen, Ross Bullock, Shyam Gajavelli, Stephen Burks, Helen Bramlett, and W Dalton Dietrich.
• Department of Neurosurgery, The Miami Project to Cure Paralysis University of Miami Miller school of Medicine, Miami, Florida.
• Ther Hypothermia Temp Manag. 2011 Dec 20; 1 (4): 185-192.

AbstractTherapeutic mild hypothermia has been used widely in brain injury. It has evaluated in numerous clinical trials, and there is strong evidence for the use of hypothermia in treating patients with several types of ischemic / reperfusional (I/R) injuries, examples being cardiac arrest and neonatal hypoxic-ischemic encephalopathy.In spite of many basic research projects demonstrating effectiveness, therapeutic hypothermia has not been proven effective for the heterogeneous group of traumatic brain injury patients in multicenter clinical trials. In the latest clinical trial, however, researchers were able to demonstrate the significant beneficial effects of hypothermia in one specific group; patients with mass evacuated lesions. This suggested that mild therapeutic hypothermia might be effective for I/R related traumatic brain injury.In this article we have reviewed much of the previous literature concerning the mechanisms of I/R injury to the protective effects of mild therapeutic hypothermia.

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