• Experimental neurology · Oct 2000

    Sensitivity of NGF-responsive dorsal root ganglion neurons to semaphorin D is maintained in both neonatal and adult mice.

    • C Owesson, J Pizzey, and D Tonge.
    • Randall Institute, King's College London, Drury Lane, WC2B 5RL, United Kingdom.
    • Exp. Neurol. 2000 Oct 1; 165 (2): 394-8.

    AbstractUsing a coculture assay of DRG neurons and aggregates of cells transfected with individual semaphorins, we have investigated the ability of semaphorins A, D, and E to inhibit axonal growth from DRG neurons. We show that axons of these neurons that grow in response to NGF remain responsive to semaphorin D in neonatal and in adult mice, although sensitivity may decline in the latter. Consistent with these findings, expression of the semaphorin receptor, neuropilin-1, is maintained in the DRGs of adult mice.Copyright 2000 Academic Press.

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