• You-Mei Li and Xue-Yuan Liu.
• Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 20090, China.
• J. Neurol. Sci. 2015 May 15; 352 (1-2): 68-73.

ObjectiveThe aim of this study is to assess the prognostic value of systemic inflammation, as measured by the inflammatory biomarkers PCT and Hs-CRP, to predict the long-term mortality in ischemic stroke patients.MethodsWe prospectively studied 374 patients with ischemic stroke who were admitted within 24h after the onset of symptoms. Serum levels of PCT, Hs-CRP and NIH stroke scale (NIHSS) were measured at the time of admission. Clinical follow-up was performed at 1 year. The prognostic value of PCT to predict the mortality within one year was compared with Hs-CRP, NIHSS and with other known outcome predictors.ResultsIn the 64 non-survival patients, serum PCT levels were significantly (P<0.0001) higher compared with those in survival patients. Multivariate COX regression analysis showed that log-transformed PCT and Hs-CRP were independent mortality predictors with adjusted hazard ratio of 4.24 (95% confidence interval [CI], 2.42-6.30) and 15.37 (95% confidence interval [CI], 3.25-41.08). The area under the receiver operating characteristic curve of PCT and Hs-CRP were 0.89 (95% CI, 0.85-0.93) and 0.68 (95% CI, 0.59-0.77) for mortality, respectively.ConclusionSerum levels of PCT and HS-CRP at admission were independent predictor of long-term mortality after ischemic stroke in a Chinese sample.Copyright © 2015 Elsevier B.V. All rights reserved.

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