• J Retamal, G Bugedo, A Larsson, and A Bruhn.
• Facultad de Medicina, Departamento de Medicina Intensiva, Pontificia Universidad Católica de Chile, Santiago, Chile.
• Acta Anaesthesiol Scand. 2015 Oct 1; 59 (9): 1161-9.

BackgroundPositive end-expiratory pressure (PEEP) improves gas exchange and respiratory mechanics, and it may decrease tissue injury and inflammation. The mechanisms of this protective effect are not fully elucidated. Our aim was to determine the intrinsic effects of moderate and higher levels of PEEP on tidal recruitment/derecruitment, hyperinflation, and lung mechanics, in patients with acute respiratory distress syndrome (ARDS).MethodsNine patients with ARDS of mainly pulmonary origin were ventilated sequential and randomly using two levels of PEEP: 9 and 15 cmH2 O, and studied with dynamic computed tomography at a fix transversal lung region. Tidal recruitment/derecruitment and hyperinflation were determined as non-aerated tissue and hyperinflated tissue variation between inspiration and expiration, expressed as percentage of total weight. We also assessed the maximal amount of non-aerated and hyperinflated tissue weight.ResultsPEEP 15 cmH2 O was associated with decrease in non-aerated tissue in all the patients (P < 0.01). However, PEEP 15 cmH2 O did not decrease tidal recruitment/derecruitment compared to PEEP 9 cmH2 O (P = 1). In addition, PEEP 15 cmH2 O markedly increased maximal hyperinflation (P < 0.01) and tidal hyperinflation (P < 0.05). Lung compliance decreased with PEEP 15 cmH2 O (P < 0.001).ConclusionIn this series of patients with ARDS of mainly pulmonary origin, application of high levels of PEEP did not decrease tidal recruitment/derecruitment, but instead consistently increased tidal and maximal hyperinflation.© 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

19 keywords...

hide…