• Neuroscience letters · Oct 2013

    Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity.

    • Mathias Leinders, Liesbeth Knaepen, Marc De Kock, Claudia Sommer, Emmanuel Hermans, and Ronald Deumens.
    • Institute of Neuroscience, Group of Neuropharmacology, Université catholique de Louvain, Avenue Hippocrate B1.54.10, 1200 Brussels, Belgium; Department of Neurology, University of Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany.
    • Neurosci. Lett. 2013 Oct 25; 554: 146-50.

    AbstractSpinal microglial activation plays a major role in the development of neuropathic pain following peripheral nerve injury. We here provide evidence for an elevated expression of the microglial marker Iba-1 in the lumbar dorsal horn ipsilateral to L5 spinal nerve transection that persists for at least 14 weeks, a time at which mechanical hypersensitivity had fully resolved. Iba-1 expression was, however; significantly lower than at 4 weeks. We therefore conclude that microglia remain partly activated beyond the phase of pain hypersensitivity. Thus, the relation between microglial cells and neuropathic pain outcome is subject to change over time after nerve injury.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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