• H-L Sim and K-Y Tan.
• Department of Surgery, Colorectal Service, Alexandra Health, Khoo Teck Puat Hospital, Singapore, Singapore.
• Colorectal Dis. 2014 Aug 1; 16 (8): O283-7.

BackgroundOpen haemorrhoidectomy has been associated with considerable postoperative pain and discomfort. Perianal intradermal injection of methylene blue has been shown to ablate perianal nerve endings and may bring about temporary pain relief after haemorrhoidectomy. We hypothesized that the administration of intradermal methylene blue would reduce postoperative pain during the initial period after surgery.MethodA randomized, prospective, single-blind placebo-controlled trial was conducted. Patients were randomized to intradermal injection at haemorrhoidectomy of either 4 ml 1% methylene blue and 16 ml 0.5% marcaine or of 16 ml 0.5% marcaine and 4 ml saline prior to surgical dissection. Patients were asked to fill in a pain diary with a visual analogue scale. The primary outcome measure was pain score and analgesic use. Secondary outcomes were complications.ResultsThere were 37 patients in the methylene blue arm and 30 patients in the placebo arm. There were no statistically significant differences in the sex, type of haemorrhoid, number of haemorrhoids excised, duration of surgery or hospital stay. The mean pain scores were significantly lower and the use of paracetamol was also significantly less in the methylene blue group during the first three postoperative days. The risk ratio of acute urinary retention occurring when methylene blue was not used was 2.320 (95% CI 1.754-3.067). Other complication rates were not significantly different.ConclusionPerianal intradermal injection of methylene blue was useful in reducing the initial postoperative pain of open haemorrhoidectomy.Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland.

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