• Eur. J. Pharmacol. · Jan 1999

    Comparative Study

    Endogenous noradrenergic tone controls symptoms of allodynia in the spinal nerve ligation model of neuropathic pain.

    • M Xu, V K Kontinen, and E Kalso.
    • Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland. mei.xu@helsinki.fi
    • Eur. J. Pharmacol. 1999 Jan 29; 366 (1): 41-5.

    AbstractEndogenous inhibitory controls were studied in the spinal nerve ligation model of neuropathic pain. Atipamezole, a selective alpha2-adrenoceptor antagonist, produced both mechanical and cold allodynia in those rats which had not developed clear neuropathic symptoms. The same doses (50 microg i.t. or 1 mg/kg s.c.) did not increase the severity of symptoms in rats which had developed them. The opioid receptor antagonist naloxone (20 microg i.t. or 1 mg/kg s.c.) had no effect on the neuropathic symptoms. These results indicate that mechanical and cold allodynia are under endogenous noradrenergic rather than opioidergic control in this model of neuropathic pain.

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