• Eur. J. Pharmacol. · Jan 1980

    Paradoxical effect of naloxone on nitrous oxide analgesia in man.

    • M A Gillman, L Kok, and F J Lichtigfeld.
    • Eur. J. Pharmacol. 1980 Jan 25; 61 (2): 175-7.

    AbstractThe effect of naloxone on nitrous oxide analgesia in man has been investigated. The paradoxical response so obtained indicates the possibility of a dural system mediating the pain response in man. These results support previous animal experiments indicating that nitrous oxide analgesia is mediated by the opiate receptors.

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