• Science · Nov 1976

    Nitrous oxide "analgesia": resemblance to opiate action.

    • B A Berkowitz, S H Ngai, and A D Finck.
    • Science. 1976 Nov 26; 194 (4268): 967-8.

    AbstractNitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.

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