• J. Heart Lung Transplant. · May 2009

    Levosimendan: a new therapeutic option in the treatment of primary graft dysfunction after heart transplantation.

    • Florian Weis, Andres Beiras-Fernandez, Ingo Kaczmarek, Ralf Sodian, Felix Kur, Marion Weis, Michael Schmoeckel, and Bruno Reichart.
    • Department of Anesthesiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
    • J. Heart Lung Transplant. 2009 May 1; 28 (5): 501-4.

    AbstractPrimary graft dysfunction after heart transplantation is a severe complication generally related to prolonged ischemia time, size mismatch, or poor quality of the organ. Current therapeutic options include pharmacologic inotropic support with catecholamines or phosphodiesterase inhibitors, and mechanical circulatory support. We report 12 patients who received levosimendan, a new Ca(2+) sensitizer, as adjunctive inotropic support. The patients showed a rapid reduction of the doses of inotropic drugs, and no patient needed mechanical support. Levosimendan may be a useful, adjunctive inotropic drug in the treatment of patients with primary graft dysfunction after heart transplantation.

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