• Chizuko Yokoe, Hiroshi Hanamoto, Aiji Boku, Mitsutaka Sugimura, Yoshinari Morimoto, Chiho Kudo, and Hitoshi Niwa.
• Clinical Fellow, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
• Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug 1; 118 (2): 166-73.

ObjectiveDecrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation.Study DesignTwenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n=13) or a combined technique using 20% N2O and propofol (group N+P, n=13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5μg/mL. Hemodynamic and autonomic parameters were measured.ResultsMean arterial pressure decreased in both groups, the hypotensive response in group N+P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N+P than in group P.ConclusionsAddition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.Copyright © 2014 Elsevier Inc. All rights reserved.

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