• Eun Joo Lee, Ji-Youn Lim, Sang Yeub Lee, Seung Hyeon Lee, Kwang Ho In, Se Hwa Yoo, Donggeun Sul, and Sanghoon Park.
• Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Republic of Korea. pulsy@korea.ac.kr
• Clin. Biochem. 2012 Apr 1; 45 (6): 493-8.

ObjectivesWe studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma.Design And MethodsAIM were measured by using plasma and BALF sampling obtained from ARDS group (n=12) and non-ARDS group (n=12).ResultsIn the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF.ConclusionAlteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

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