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- T Tang, M H Gao, and H Kirk Hammond.
- Department of Medicine, University of California San Diego, CA, USA.
- Gene Ther. 2012 Jun 1; 19 (6): 606-12.
AbstractCongestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congestive heart failure, paracrine-based gene transfer.
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