Gastrointestinal bleeding associated with rivaroxaban

Swiss medical weekly · Jan 2014

Case Reports

Gastrointestinal bleeding associated with rivaroxaban administration in a treated patient infected with human immunodeficiency virus.

The use of rivaroxaban in fixed dosing regimens without need for routine coagulation monitoring may lead to the misconception that there is a minimal risk of drug-drug interactions. We describe the case of a patient infected with human immunodeficiency virus (HIV) on salvage therapy who developed gastrointestinal bleeding while receiving the standard dose of rivaroxaban for the prevention of venous thromboembolism after surgery. This case clearly sends a warning that protease inhibitors should not be co-administered with rivaroxaban. Furthermore, it highlights the importance of clinicians' caution about potential drug-drug interactions.

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- Botond Lakatos, Marcel Stoeckle, Luigia Elzi, Manuel Battegay, and Catia Marzolini.
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland.
- Swiss Med Wkly. 2014 Jan 1; 144: w13906.
AbstractThe use of rivaroxaban in fixed dosing regimens without need for routine coagulation monitoring may lead to the misconception that there is a minimal risk of drug-drug interactions. We describe the case of a patient infected with human immunodeficiency virus (HIV) on salvage therapy who developed gastrointestinal bleeding while receiving the standard dose of rivaroxaban for the prevention of venous thromboembolism after surgery. This case clearly sends a warning that protease inhibitors should not be co-administered with rivaroxaban. Furthermore, it highlights the importance of clinicians' caution about potential drug-drug interactions.

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Gastrointestinal bleeding associated with rivaroxaban administration in a treated patient infected with human immunodeficiency virus.

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