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- Bruce K Rubin.
- Department of Pediatrics, Virginia Commonwealth University School of Medicine, and the Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia. brubin@vcu.edu.
- Respir Care. 2015 Jun 1;60(6):825-9; discussion 830-32.
AbstractAirway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce hypersecretion, make secretions easier to transport, or increase the efficiency of cough or mucus clearance. In this paper, I review the pathophysiology of secretory hyper-responsiveness and mucus hypersecretion and discuss the different aerosol medications that can be used to augment secretion clearance.Copyright © 2015 by Daedalus Enterprises.
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