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Bmc Musculoskel Dis · Jan 2015
Case ReportsSystemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report.
- Laura Niccoli, Emanuele Cassarà, Olga Kaloudi, Carlotta Nannini, Micaela Romagnoli, and Fabrizio Cantini.
- Consultant in Rheumatology, Rheumatology Division, Hospital of Prato, Prato, Italy. lniccoli64@gmail.com.
- Bmc Musculoskel Dis. 2015 Jan 1; 16: 146.
BackgroundAsbestosis is characterized by lung and pleural fibrosis and by immune system dysregulation, with autoantibody production and systemic immune-mediated disease. No specific therapies are available for asbestosis. Recently, the pivotal pathogenic role exerted by interleukin-1beta has been recently reported.Case PresentationWe treated with anti-interleukin 1 beta targeted antibody canakinumab a 67 year old man with asbestosis and long lasting systemic autoimmune features. A dramatic improvement in clinical manifestations was observed at 1 week after the first injection, with complete clinical remission at 4 months.ConclusionThis case suggests new perspectives for the treatment of asbestosis and its systemic features.
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