-
- N J Halliday, J W Dundee, P S Collier, P G Loughran, and K W Harper.
- Anaesthesia. 1985 Aug 1; 40 (8): 763-6.
AbstractThe action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
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