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Randomized Controlled Trial
Modulation of serum BDNF levels in postherpetic neuralgia following pulsed radiofrequency of intercostal nerve and pregabalin.
- Ashok Kumar Saxena, Kavitha Lakshman, Tusha Sharma, Neha Gupta, Basu Dev Banerjee, and Archana Singal.
- Pain Clinic, Division under Department of Anaesthesiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
- Pain Manag. 2016 Jan 1; 6 (3): 217-27.
AimTo study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN).Materials & MethodsA randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment.ResultsPain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group.ConclusionIntegrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.
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