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Anasthesiol Intensivmed Notfallmed Schmerzther · Sep 2003
Case Reports[Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?].
- A Lehmann, J Boldt, J Lang, F Isgro, and M Blome.
- Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen, Germany. Dr. A.Lehmann@web.de
- Anasthesiol Intensivmed Notfallmed Schmerzther. 2003 Sep 1; 38 (9): 577-82.
AbstractLevosimendan, is a new calcium sensitiser with 2 major effects. First, levosimendan acts as a positive inotropic agent by binding calcium dependently to cardiac troponin C. Second, levosimendan activates adenosine triphosphate-regulated potassium (K (ATP)) channels. Thus it has vasodilatory properties and cardioprotective effects at a dose enhancing myocardial contractility. These unique properties of levosimendan might be of great advantage in patients with myocardial ischemia simultaneously requiring inotropic support. The concept of perioperative inoprotection is presented in 6 patients with acute ischemia undergoing emergent cardiac surgery.
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