• Shock · Dec 2005

    Review

    Large animal models: baboons for trauma, shock, and sepsis studies.

    • Heinz Redl and Soheyl Bahrami.
    • Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, A-1200 Vienna, Austria. office@lbitrauma.org
    • Shock. 2005 Dec 1; 24 Suppl 1: 88-93.

    AbstractA few limited examples of large animal models are outlined, with the main emphasis on baboon models. The baboon offers all the advantages of a large animal and is comparable with humans in nearly all physiological and immunological aspects. In addition, cross-reactivity with human therapeutic and diagnostic reagents allows testing of new species-specific therapies such as antihuman antibodies, on the one hand, and monitoring with available human analytical procedures, on the other.

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