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Neuroendocrinol Lett · Aug 2008
Effect of selenium compound (selol) on the opioid activity in vincristine induced hyperalgesia.
- Magdalena Bujalska and Stanisław Witold Gumułka.
- Department of Pharmacodynamics, Medical University of Warsaw, Warsaw, Poland. mbujalska@gmail.com
- Neuroendocrinol Lett. 2008 Aug 1; 29 (4): 552-7.
PurposeEffect of organoselenium compound (selol), on antinociceptive action of opioid agonists in vincristine neuropathic pain model was investigated.MethodsThe changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto.ResultsDaily administration of VIN (70 microg/kg, iv) resulted in progressive decrease of pain threshold. Neither morphine, fentanyl nor buprenorphine administered alone in 5 consecutive days modified the vincristine-induced hyperalgesia, whereas selol slightly increased the nociceptive threshold. Co-administration of selol with opioids markedly enhanced the analgesic activity of all three investigated compounds.ConclusionsTherefore, concomitant administration of selenium and opioids may be beneficial in terminal neoplastic states.
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