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- T Watanabe and M Washio.
- Second Department of Surgery, Yamagata University School of Medicine, Japan.
- Ann. Thorac. Surg. 1993 Dec 1; 56 (6): 1478-81.
AbstractWe examined the oxygen tension, carbon dioxide tension, and pH in canine brains under profound hypothermia to evaluate the effects of perfusion (circulatory arrest for 1 hour; 25 and 50 mL.kg-1 x min-1 for 2 hours) with and without pulsatile assistance. The effects of pulsatile flow on cerebral blood flow and metabolism were also evaluated in dogs supported by low-flow perfusion (25 mL.kg-1 x min-1) for 2 hours. Profound hypoxia occurred in the brain after 20 to 60 minutes of circulatory arrest. Brain tissue acidosis with hypercapnia was moderated by perfusion at a rate of flow of 50 mL.kg-1 x min-1. Pulsatile low-flow perfusion (25 mL.kg-1 x min-1) moderated cerebral hypercapnia and made the cerebral metabolism aerobic without affecting the total cerebral blood flow and consumption of oxygen.
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