• Shinji Kawahito, Shuji Haraguchi, Tomohiro Maeda, Tadashi Motomura, Tamaki Takano, Kenji Nonaka, Joerg Linneweber, Seiji Ichikawa, Masaki Kawamura, Hiroshi Ishitoya, Julie Glueck, Koshiro Sato, and Yukihiko Nosé.
• Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA.
• Ann Thorac Cardiovasc Surg. 2002 Feb 1; 8 (1): 7-11.

AbstractBased on the results of many experimental models, a hollow fiber silicone membrane oxygenator applicable for long-term extracorporeal membrane oxygenation (ECMO) was developed. For further high performance and antithrombogenicity, this preclinical model was modified, and a new improved oxygenator was successfully developed. In addition to ECMO application, the superior biocompatibility of silicone must be advantageous for pediatric cardiopulmonary bypass (CPB). An ex vivo short-term durability test for pediatric CPB was performed using a healthy miniature calf for six hours. Venous blood was drained from the left jugular vein of a calf, passed through the oxygenator and infused into the left carotid artery using a Gyro C1E3 centrifugal pump. For six hours, the O2 and CO2 gas transfer rates were maintained around 90 and 80 ml/min at a blood flow rate of 2 L/min and V/Q=3, respectively. The plasma free hemoglobin was maintained around 5 mg/dl. These data suggest that this newly improved oxygenator has superior efficiency, less blood trauma, and may be suitable for not only long-term ECMO but also pediatric CPB usage.

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