• Sheng Li Ke Xue Jin Zhan · Jul 2001

    Review

    [Analgesic mechanisms of noradrenaline in the spinal dorsal horn].

    • Y P Feng, K Yang, and Y Q Li.
    • Department of Anatomy, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032.
    • Sheng Li Ke Xue Jin Zhan. 2001 Jul 1; 32 (3): 225-8.

    AbstractThe superficial laminae of the spinal dorsal horn play important roles in nociceptive transmission and modulation. Noradrenergic fibers originated from brainstem pain-control system terminate and release noradrenaline (NA) in the superficial dorsal horn. The released NA might take part in the modulation of nociceptive transmission through the following pathways: (1) inhibits the glutamate and substance P release from primary afferent terminals; (2) increases the release of inhibitory neurotransmitters from lamina II (substantia gelatinosa) neurons. Morphological findings also raise the possibility that NA directly inhibits projection neurons in laminae I/III which convey the nociceptive information to the thalamus, thus inhibit nociceptive transmission at spinal level.

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