• J. Pharmacol. Sci. · Jan 2012

    Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice.

    • Víctor Fernández-Dueñas, Raquel Poveda, Sílvia Sánchez, and Francisco Ciruela.
    • Unit of Pharmacology, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, The University of Barcelona, Spain. vfernandez@ub.edu
    • J. Pharmacol. Sci. 2012 Jan 1; 118 (2): 299-302.

    AbstractMultimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice. The three-drug combined treatment displayed a potent synergistic antinociceptive effect, together with a significant reduction of gastrointestinal transit inhibition. Furthermore, selective µ- and κ-opioid receptor antagonists reversed these synergistic antinociceptive effects, thus suggesting a pivotal role of the opioid system. Overall, this study presents accurate pre-clinical data that might be useful to improve the clinical management of opioid-mediated analgesia.

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