• Antimicrob. Agents Chemother. · Jun 2008

    Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.

    • Marc H Scheetz, Stephanie A Knechtel, Michael Malczynski, Michael J Postelnick, and Chao Qi.
    • Midwestern University Chicago College of Pharmacy, Infectious Diseases Pharmacist, Northwestern Memorial Hospital, 251 E. Huron St., Feinberg Pavilion LC-700, Chicago, IL 60611, USA. mscheetz@nmh.org
    • Antimicrob. Agents Chemother. 2008 Jun 1; 52 (6): 2256-9.

    AbstractClinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

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