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Int. J. Antimicrob. Agents · Apr 2006
Case ReportsEmergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis.
- Ana C Gales, Hélio S Sader, Soraya S Andrade, Larissa Lutz, Adão Machado, and Afonso L Barth.
- Laboratório Alerta, Universidade Federal de São Paulo, São Paulo, Brazil. galesac@aol.com
- Int. J. Antimicrob. Agents. 2006 Apr 1; 27 (4): 300-2.
AbstractWe report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. The strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. The strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance.
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