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Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Dec 2014
Research advances in the application of methylprednisolone in the treatment of acute spinal cord injury.
- Xiang-Yi Kong, Jun Gao, Yi Yang, Yong-Ning Li, Wen-Bin Ma, Bing Xing, and Ren-Zhi Wang.
- Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Dec 1; 36 (6): 680-5.
AbstractAcute spinal cord injury(ASCI),mainly caused by traffic accidents and fall injuries,is a catastrophic event that can profoundly affect the trajectory of a patient's life. Debate continues over the medical management of ASCI,in particular the usefulness,dosage,and potential risks of methylprednisolone(MP). Although the results of American National Acute Spinal Cord Injury Study 2 and 3 trials led to the wide adoption of a high-dose MP regimen for ASCI patients,the reliabilities of their study methods and data were still questionable. Based on the currently available literature,we conclude that high-dose MP is no longer a recommended therapy for ASCI;however,due to the lack of effective treatment,it remains a useful option for this condition.
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