• Clinics in chest medicine · Sep 2008

    Review

    The immunology of sarcoidosis.

    • Alicia K Gerke and Gary Hunninghake.
    • Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. alicia-gerke@uiowa.edu
    • Clin. Chest Med. 2008 Sep 1; 29 (3): 379-90, vii.

    AbstractSarcoidosis continues to be a disease of research interest because of its complicated immune mechanisms and elusive etiology. So far, it has been established that granulomatous inflammation in sarcoidosis is predominantly a T-helper 1 immune response mediated by a complex network of lymphocytes, macrophages, and cytokines. The cause of progression to a chronic and potentially fibrotic form is unclear but may involve loss of apoptotic mechanisms, loss of regulatory response, or a persistent antigen that cannot be cleared. Recent genomic and proteomic technology has emphasized the importance of host susceptibility and gene-environment interaction in the expression of the disease.

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