• Leukemia research · Feb 2012

    Single dose palonosetron and dexamethasone in preventing nausea and vomiting induced by high emetogenic ABVD regimen in Hodgkin Lymphoma patients.

    • Luigi Rigacci, Carla Landi, Jean Pierre Caruso, Benedetta Puccini, Renato Alterini, Valentina Carrai, Tania Perrone, and Alberto Bosi.
    • Haematology Department, Azienda Ospedaliero Universitaria Careggi, Largo Brambilla, 3 50139 Firenze, Italy. luigi.rigacci@unifi.it
    • Leuk. Res. 2012 Feb 1; 36 (2): 182-5.

    AbstractTo evaluate the efficacy of a new agent, palonosetron, in Hodgkin Lymphoma patients treated with ABVD regimen. Complete response during the overall phase of the first ABVD cycle, was the primary endpoint. Secondary end points were: emesis-free patients and use of rescue medication during the acute and overall phases. From January 2008 to February 2009 36 patients were enrolled. The primary endpoint (CR 0-120 h) was achieved by 55.6% patients. In conclusion our study demonstrated that a single dose of palonosetron plus a single dose of dexamethasone was effective in preventing CINV in patients treated with ABVD regimen.Copyright © 2011 Elsevier Ltd. All rights reserved.

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