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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison between alfentanil, pethidine and placebo in the treatment of post-anaesthetic shivering.
- I J Wrench, G Cavill, J E Ward, and A W Crossley.
- Department of Anaesthesia, Royal Hallamshire Hospital, Sheffield.
- Br J Anaesth. 1997 Oct 1; 79 (4): 541-2.
AbstractWe have compared the effects of pethidine, alfentanil and placebo in the treatment of post-anaesthetic shivering. Ninety patients who shivered after routine surgery were allocated randomly to receive normal saline (n = 30), alfentanil 250 micrograms (n = 30) or pethidine 25 mg (n = 30). After 10 min, 26 patients had stopped shivering in the pethidine group which was significantly more than the incidence in the two other groups (placebo = 7; alfentanil = 12) (P < 0.0002). Alfentanil was not significantly different from normal saline in affecting shivering. We conclude that alfentanil 250 micrograms was not effective in the treatment of post-anaesthetic shivering.
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