• Vali Imantalab, Ali Mirmansouri, Abbas Sedighinejad, Bahram Naderi Nabi, Farnoush Farzi, Hadi Atamanesh, and Nassir Nassiri.
• Anesthesiology Department, Guilan University of Medical Sciences, Rasht, Iran.
• Anesth Pain Med. 2014 Oct 1; 4 (4): e19423.

BackgroundSimple and efficient way of pain management after Coronary Artery Bypass Graft (CABG) surgery is an important aspect of patients' care.ObjectivesThis study aimed to compare the effects of morphine and diclofenac suppositories on postoperative pain management.Patients And MethodsIn this double-blinded clinical trial study, 120 patients aged 30-65 years old, undergone CABG, were equally divided into two groups of A (morphine) and B (diclofenac). All patients were anesthetized with intravenous fentanyl 10 μg/kg, etomidate 0.2 mg/kg and cisatracurium 0.2 mg/kg. Anesthesia was maintained with oxygen 50% and air 50%, propofol 50 μg/kg/min, fentanyl 1-2 μg/kg/h and atracurium 0.6 mg/kg/h. Analgesics were administered after the operation at intensive care unit (ICU) and Visual Analogue Score (VAS) was evaluated in both groups in 4-hour intervals after extubation for 24 hours. After extubation in case of VAS > 3, morphine suppository 10 mg (group A) or diclofenac suppository 50 mg (group B) was administered for patients.ResultsNo significant statistical relationship was found between the two groups regarding gender, age, BMI, paracetamol consumption, length of operation time, cardiopulmonary bypass pump (CPB) time, and stay time at ICU (P Value ≥ 0.05). Total dosage of used morphine was 22 ± 8.3 mg in each patient and total dosage of used diclofenac was 94 ± 32.01 mg. Average variation of VAS at measured intervals was significant (P Value ≤ 0.0001), but these variations were not significantly different when comparing the two groups (P Value = 0.023).ConclusionsBoth morphine and diclofenac suppositories reduced pain significantly and similarly after CABG surgery.

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