• Biom J · Aug 2006

    Comment

    Adaptive designs from the viewpoint of an academic biostatistician.

    • Helmut Schäfer.
    • Institute of Medical Biometry and Epidemiology, Philipps-University Marburg, Germany. hsimbe@med.uni-marburg.de
    • Biom J. 2006 Aug 1; 48 (4): 586-90; discussion 613-22.

    AbstractThis is a discussion of the following three papers appearing in this special issue on adaptive designs: 'FDA's critical path initiative: A perspective on contributions of biostatistics' by Robert T. O'Neill, 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; and 'Confirmatory clinical trials with an adaptive design' by Armin Koch.

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