• M Alvarez del Castillo.
• ICU Hospital Mútua de Terrassa, Plaza Dr. Robert 5, 08221 Terrassa, Barcelona, Spain. maxi@sumi.es
• Curr Opin Crit Care. 2001 Apr 1; 7 (2): 49-60.

AbstractThe brain is sensitive to changes in substrate delivery. In neurologically critically ill patients (e.g., those with head injury, subarachnoid hemorrhage, or stroke), interruption of this supply causes ischemic brain damage and thus impairs the outcome. To prevent, detect, and treat these ischemic events as soon as possible, the cerebral blood flow is continuously monitored, its coupling or not with the consumption of oxygen and so forth, and the detected derangements of normal physiology. Intracranial pressure and cerebral perfusion pressure are two parameters that often reflect ischemic events, and thus it is mandatory to continuously measure them. To better assess cerebral hemodynamics, jugular bulb oxymetry and brain pressure tissue oxygen monitoring are two neuromonitoring techniques that allow for a better understanding of the balance between oxygen supply and consumption, and therefore are useful in directing therapy. Transcranial Doppler ultrasonography is a noninvasive technique with the same purpose but with less clinical relevance. The new neuromonitoring technique, microdialysis, is useful for understanding the mechanisms involved in brain ischemia. However, it is clear that the physician who interprets the measurements given by devices and the clinical data (e.g., temperature, glycemia) is still the cornerstone in the management of neurologically critically ill patients.

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