• A Sardella, D Uglietti, F Demarosi, G Lodi, C Bez, and A Carrassi.
• Department of Oral Pathology and Medicine, School of Dentistry, University of Milan, Italy.
• Oral Surg Oral Med O. 1999 Dec 1; 88 (6): 683-6.

ObjectiveThe purpose of this study was to evaluate the efficacy of the topical use of benzydamine hydrochloride 0.15% oral mouthwashes in the control of burning mouth syndrome symptoms.Study DesignIn this double-blind, randomized, longitudinal investigation, each of 30 patients with burning mouth syndrome was assigned to one of 3 management modalities. Those in group A received an oral rinse solution of benzydamine hydrochloride 0.15% 3 times a day for 4 weeks, those in group B received a placebo 3 times a day for 4 weeks, and those in group C did not receive any kind of treatment. A visual analog scale was used for evaluation of the symptoms; a Kruskal-Wallis analysis of variance exact test was performed on the resulting data.ResultsThe findings of this investigation failed to reveal significant differences among the groups.ConclusionsThe clinical application of benzydamine hydrochloride oral rinses in the treatment of patients with burning mouth syndrome did not demonstrate significative efficacy in comparison with use of a placebo solution.

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